Have you ever felt exhausted after a long day at work, going to classes or studying at the library? You should know that you are not alone. Mental fatigue is a very common problem in our modern world. But did you also know that you already have access to a nutrient that could clear your mind and help you overcome this state of mental malaise?

Vitamin B6 is essential for the proper functioning of your entire body. It activates metabolism, contributes to the development of new muscle, and maintains your nervous system at full working capacity. We’ve designed this shopping guide to share all the secrets we know regarding this fabulous vitamin with you. Are you ready to learn all about Vitamin B6 Supplements?

Key Facts

  • The term “Vitamin B6” encompasses three different substances that activate and stimulate the body’s proper metabolism.
  • Vitamin B6 is essential to the creation of hemoglobin, for the transport and synthesis of amino acids, and for the building of neurotransmitters.
  • While Vitamin B6 is considered safe even at higher doses, excessive Vitamin B6 supplement intake can result in toxicity in the long term.

Ranking: The Best Vitamin B6 Supplements on the U.S. Market

In the following section, we will outline a selection of the very best Vitamin B6 supplements available right now on the U.S. market. Taking into account factors such as value, price and customer satisfaction ratings, we have developed with this list featuring some of the highest-rated, best-selling vitamin B6 supplements available. We’re confident that you’ll find the perfect Vitamin B6 product for your individual needs on this list.

No. 1: NOW Supplements, Vitamin B-6 100 mg, 250 Capsules

First up, for under $9 per bottle of 250-100 mg capsules, NOW brand Vitamin B-6 supplement is a great value. NOW owns and operates several manufacturing and distribution facilities in the United States and Canada. These facilities also house state-of-the-art laboratories, where NOW’s quality technicians use the latest analytical instrumentation to perform internal reviews on the ingredients used in manufacture of their supplements and in all their finished products.

According to the Now corporation: Vitamin B-6 is a co-factor in numerous enzymatic reactions and is required for the metabolism of fats, carbohydrates, and proteins. It facilitates the conversion of amino acids from one to another type as needed, and is necessary for normal synthesis of hemoglobin, as well as for normal function and production of red blood cells. Vitamin B-6 plays an important role in regulating homocysteine metabolism in the body. Homocysteine, a by-product of the methionine cycle, is known to be destructive to bodily tissues, especially vascular structures. B-6 is also critical for the maintenance of a healthy nervous system.

No. 2: Nature Made Vitamin B6 100 mg Tabs, 100 ct

Trusted giant in the supplement arena, Nature Made offers 100 tablets of 100mg each for about $8.  Ninety-six percent of reviewers gave this product 4 or 5 stars.

This product’s features are as follows: Vitamin B-6 has a vital role in cell development and is critical for the proper function of our immune systems, as well as a healthy pregnancies. B-6 plays a significant role in our brain’s chemistry. Clinical studies have demonstrated its importance in certain health conditions, such as morning sickness. B-6 is essential for Protein and Amino Acid Metabolism.

No. 3: Nature’s Bounty Vitamin B6, 100mg, 100 Tablets

Nature’s Bounty is another well-known and trusted name among U.S. supplement companies. For nearly 50 years they have been making trusted products, backed by science, and made with only the purest ingredients, assured. So you can get the most out of life every day.

For just $5, this package of 100 tablets of 100mg each will provide you with the Vitamin B6 you need. Vitamin B6 supports energy production by helping convert food into energy. B-6 also plays a role in heart health, by promoting the regulation of healthy homocysteine levels, while also supporting nervous system health.

No. 4: Solgar – Vitamin B6, 25 mg, 100 Tablets

Solgar’s 100-count bottle of 25 mg B6 tablets can be purchased for less than $6 per bottle.  These tablets are suitable for vegans, are non-GMO, and are certified gluten free. They are also free of wheat, dairy, soy, yeast, sugar, sodium, artificial flavors, sweeteners, preservatives and colors.

Solgar is one of the few companies offering a lower dosage, for those who need it, and the price is very affordable.  This product averaged 4.5 stars out of 5  and many reviewers report this product as easing “morning sickness” in pregnant women.

No. 5: Nature’s Bounty Vitamin B Sublingual Liquid 2 oz (4-pack)

Also from Nature’s Bounty is Vitamin B-6 in liquid form. For just $16 for four bottles, with 59 doses per bottle, this is a great alternative for those who do not like taking pills.  Nature’s Bounty B-Complex Sublingual Liquid with Vitamin B-16 provides an excellent source of B-complex vitamins to help safeguard a sufficient daily intake. B-complex is essential for the maintenance of healthy nervous tissue. B vitamins also play a role in energy metabolism in the body.

The B vitamin complex is made up of several vitamins that work well together to support nervous system health. Each nutrient in the B vitamin complex performs a unique role in maintaining proper metabolic functioning and is essential for well-being.

Shopping Guide: Everything You Need to Know about Vitamin B6 Supplements

By acting as a co-factor of various chemical reactions, Vitamin B6 regulates over 150 processes of cellular metabolism in our bodies. This nutrient is absolutely essential to our body’s general health, and contributes to mental and physical well-being. A lack of this vitamin can lead to anemia, energy loss and mood swings, among other potential conditions.

Having optimal levels of vitamin B6 is essential for everyone’s well-being.
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What exactly is Vitamin B6?

As we mentioned above, the term “Vitamin B6” actually encompasses a group of several different molecules: pyridoxine, pyridoxal and pyridoxamine. This complex also includes certain compounds derived through the metabolism of these molecules. There are six molecules grouped under this umbrella term “Vitamin B6,” with pyridoxal phosphate (“PLP” or “P5P”) being the active form of this molecule.

Hungarian doctor Paul György first identified Vitamin B6 in 1934, identifying it as a compound capable of curing cutaneous lesions in rats suffering from malnutrition. In 1945, scientists also discovered that this vitamin exists in several different forms. Their structures are similar to that of the compound pyridine, from which its name is derived.

Skin inflammation or itching may be indicators of an intolerance to vitamin B6 supplements or one of their components.
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Vitamins – from the Latin “vita” (life) and “amine” (organic compound) – are substances essential for our bodies’ general health. Since the body cannot synthesize these substances on its own, we have to ingest these vitamins through our diets or supplements. The small intestine absorbs these ingested vitamins, and the liver metabolizes them.

Vitamin B6 is considered a “water-soluble” vitamin, meaning that it dissolves in the water present in foods. Excess intake of this vitamin is easily eliminated through urine, which is why intoxication of this vitamin is particularly unlikely. While this nutrient is found in many foods, experts estimate that up to 10% of the population suffer from some form of B6 deficiency.

What is the role of Vitamin B6?

PLP – the vitamin’s active form – promotes enzymatic reactions that regulate the metabolizing of amino acids, lipids and carbohydrates. It also fights aging by degrading and helping to eliminate oxidizing substances. We’ve listed the nine most important functions of PLP for you below:

  • Neurotransmitter synthesis: Vitamin B6 is essential for the body to be able to synthesize neurotransmitters from amino acids. These compounds – mainly serotonin, dopamine and adrenaline – play a key role in our physical and mental well-being, allowing the body to cope with the stress of daily life.
  • Brain development during childhood: Childhood is a critical period in the development of our bodies. The nervous system grows at breakneck speed during this time, and it requires adequate vitamin B6 to mature properly.
  • Transformation of amino acids: Vitamin B6 is necessary to transform certain amino acids into other compounds, which helps to maintain the proper levels of certain substances essential to the body.
  • Selenium metabolism: This antioxidant micronutrient is essential for the proper functioning of our immune system. In general selenium binds to the amino acid methionine, which requires  the inclusion of Vitamin B6 in order to be released and carry out its functions.
  • Glucose metabolism: Vitamin B6 is necessary for glycogenolysis (the release of glucose from the body’s reserves) and gluconeogenesis (creation of glucose from amino acids and other compounds). This substance therefore balances blood sugar levels according to the needs of our bodies.
  • Lipid metabolism: Vitamin B6 contributes to the formation of complex lipids that will form part of the body’s cell walls. When required, the decomposition of these compounds into simple fatty acids also depends on Vitamin B6.
  • Hemoglobin metabolism: Vitamin B6 is essential for the synthesis and proper functioning of hemoglobin, the protein responsible for transporting oxygen to all of the body’s tissues.
  • Antibody synthesis: These tiny molecules are responsible for recognizing and attacking the various pathogens that attack our bodies from time to time. Our body needs sufficient Vitamin B6 to synthesize these vital components for our immune system to function correctly.
  • Molecular and genetic regulation: Vitamin B6 is involved in several processes intended to regulate DNA. Studies are currently underway to understand these processes, but they appear to associate this substance with the different genes that may control the appearance of severe diseases such as diabetes or cancer.

These are the reasons why Vitamin B6 is seen as the mechanism that allows the body to function properly. It has a particularly strong influence on our nervous systems: this vitamin regulates our sleeping and waking cycles, our emotional health, as well as our memory and concentration capacities.

Dr. Eric BergOsteopath & Nutritionist

“Vitamin B6 is a catalyst that enables the functioning of everything [the body’s metabolic processes]. It is like the glue that holds the body together.”

What are the symptoms of a Vitamin B6 deficiency?

As we mentioned earlier, Vitamin B6 is water soluble and therefore easily excreted in the urine. While this reduces the likelihood of vitamin toxicity due to the presecence of an excess of this substance in the body, it also exposes one to a deficiency if these losses are not compensated for in other ways. A person may suffer one or more of the symptoms listed below due to a Vitamin B6 deficit:

  • Fatigue: Vitamin B6 is essential for the metabolism of hemoglobin and glucose. Its deficiency can lead to anemia, making it harder to obtain energy from carbohydrates. This will in turn cause a state of tiredness, apathy and constant fatigue.
  • Increased susceptibility to infections: Without enough Vitamin B6, your immune system will weaken if you cannot produce the antibodies and proteins that help protect your body fight against pathogens. This may lead to the development of all kinds of infections and illnesses.
  • Mood swings: Low levels of Vitamin B6 will make it harder for your body to produce neurotransmitters such as serotonin and dopamine. You could therefore experience unpleasant symptoms such as mood swings or unexplained moments of sadness and irritability. This may also lead to an aggravation of the symptoms of premenstrual syndrome (PMS) in women.
  • Dry and cracked lips: A Vitamin B6 deficiency will promote the appearance of dry and cracked lips. Similarly, a Vitamin B6 deficiency can lead to an increased likelihood of suffering from “angular cheilitis” – very painful fissures in the corner of the lips.
  • Tongue swelling: Known as “glossitis,” this inflammation of the tongue that makes it appear red and swollen is a consequence of the loss of taste buds. Other nutritional deficiencies such as Vitamin B12 deficit can also cause this condition.
  • Cutaneous inflammation: Your skin status will considerably worsen when B6 levels fall below normal. A decrease in B6 levels to below normal numbers will significantly worsen the condition of your skin. It is possible that patches of red, inflamed skin, and even an inflammation that causes itching and scaling, known as “seborrheic dermatitis,” may appear.
  • Unpleasant sensations in feet and hands: Vitamin B6 is essential for neural health. A deficit of this important vitamin can cause damage to our neurons and nerve endings, first affecting the nerves of the more peripheral regions. There will be unpleasant sensory sensations such as numbness, tingling, itching and even pain, known as “peripheral neuropathy.”
  • Increased homocysteine levels: Homocysteine is a derivative of protein metabolization. Its prevalence is related to an increase in the frequency of the appearance of degenerative diseases at cardiac and cerebral levels. Some studies link a decrease in Vitamin B6 with an increase of this homocysteine.
  • Increased chance of developing kidney stones: Some studies have linked low Vitamin B6 levels with increased formation of oxalate stones at the renal level (commonly known as “kidney stones”).

If Vitamin B6 deficiency is particularly severe, convulsions may occur as a result of excessive neural stress. This condition is especially severe in children. In the long term, low levels of this vitamin have also been linked to an increased incidence of dementia, diabetes and even cancer.

Vitamin B6 can be found in many food groups including meat, carbohydrate, vegetable and fruit.
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Who has an increased risk of Vitamin B6 deficiency?

While it is very rare to find absolutely no Vitamin B6 in the blood of a human, experts believe that up to 10% of the individuals in the groups listed below have suboptimal (20-29 nmol/L) concentrations of this nutrient.

  • People being treated with isoniazid, hydralazine or penicillamine: These three medications may interfere with PLP metabolism, leading to abnormally low levels of this substance.
  • Women using oral contraceptives: We have known for years about the relationship between the use of estrogen formulas and decreased Vitamin B6 levels. While new-generation contraceptives present fewer side effects, they can still lead to lower levels of this nutrient.
  • Individuals with impaired renal function: A diseased kidney cannot prevent excessive elimination of certain nutrients. This is why renal pathologies are often linked to a decrease in Vitamin B6 levels.
  • Individuals with autoimmune diseases: Autoimmune conditions provoke an inflammatory state that uses and depletes the body’s B6 vitamin reserves. The deficiency will worsen as the autoimmune disorder progresses.
  • People with alcohol dependence: This extremely oxidizing substance can consume large quantities of Vitamin B6 and decrease its levels to below normal.
  • Smokers: The oxidizing effect of the chemicals found in tobacco may contribute to several nutritional deficiencies, including Vitamin B6.
  • Diabetic individuals: Diabetes has been associated with inadequate Vitamin B6 levels. Experts still debate whether this decrease is a consequence of increased blood glucose levels, or whether decreased levels of this vitamin impact insulin production, therefore aggravating diabetes.
  • Lactating women: Breast milk is rich in many nutrients, including Vitamin B6. Women producing this natural food have higher nutritional requirements.
  • Gluten-intolerant individuals: If celiac disease is not well-monitored, it may lead to a state of intestinal malabsorption that will hinder the body’s assimilation of Vitamin B6 and expose the sufferer to some degree of hypovitaminosis.
  • Obese individuals: While the mechanism behind this is still unknown, obesity has also been associated with a decrease in Vitamin B6 levels. Supplementing with this vitamin contributes weight loss and helps maintain body mass within a healthy range.
  • Elderly people: It is very common for older individuals to suffer from different food deficiencies as a result of a difficulty in feeding themselves and the loss of appetite linked with ageing.

Vitamin B6 deficiency often happens in conjunction with a pathological decrease in the levels of other B vitamins. The deficit of B6 only has rarely been observed, generally occurring in hereditary genetic disorders that hinder or prevent the synthesis of PLP, the active form of Vitamin B6.

What is the recommended daily intake of Vitamin B6?

Vitamin B6 is part of the group of life-sustaining substances, for which experts establish a set of nutritional guidelines that limit the minimum and maximum allowance that should be taken to maintain healthy B6 levels. The latest scientific studies are used to review and update these numbers.

Lentils are high in Vitamin B6 and fiber.
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The recommended daily allowance (RDA) is the the minimum amount of a nutrient that must be consumed in order to maintain healthy levels in the blood. This value is approximately 30 nmol/L (nanomole per liter) for Vitamin B6. In the table below, we detail the RDA for  different population groups:

Population group Vitamin B6 RDA (mg)
Babies up to 6 months 0.1
Babies between 7 and 12 months 0.3
Children between 1 and 3 years 0.5
Children between 4 and 8 years 0.6
Children between 9 and 13 years 1
Teenagers between 14 and 18 years 1.3
Adults between 19 and 50 1.3
Women over 50 1.5
Men over 50 1.7
Pregnant women 1.9
Lactating women 2

These recommendations establish a rough guide for healthy individuals who maintain their digestive, absorptive and metabolic capacities in a healthy condition. Any alteration of the normal health ystatus will provoke a variation in the nutritional needs that will result in the need to consult with a health professional.

What foods are rich in Vitamin B6?

Our bodies cannot store Vitamin B6 in the same way we store fat-soluble vitamins – Vitamins A, D, E, and K). This is why we need to receive our daily intake of this nutrient through our diet. Vitamin B6 is abundant in animal foods and unrefined whole grains.

In order to obtain a healthy intake of this vitamin, it is recommended that individuals follow a diet which includes a variety of fresh meat, fish, vegetables and nuts. In the table below, we have detailed the Vitamin B6 content found in some of the foods most frequently used in our diet:

Food (100 g or 100 ml) Vitamin B6 content (mg) % RDA (adults 19-50 years)
Pistachios 1.7 130%
Tuna 1 78%
Salmon (cooked) 0.8 62%
Chickpeas (canned) 0.5 39%
Veal 0.4 31%
Whole grains 0.4 31%
Chicken breast (grilled) 0.4 31%
Banana 0.3 23%
Avocado 0.3 23%
Spinach (raw) 0.3 23%
Sweet potatoes (roasted) 0.3 23%
Potatoes (cooked with skin) 0.3 23%
Lentils (cooked) 0.2 15%
Oatmeal 0.2 15%
Peas (cooked) 0.15 12%
Brown rice 0.1 8%
Cream cheese 0.1 8%
Eggs (two medium-sized) 0.1 8%
Carrot (raw) 0.14 8%
Whole cow’s milk 0.04 3%

Do not despair if you are a vegan.  There are many different sources of Vitamin B6 that are free of animal products. This means that vegan and vegetarian individuals can easily meet their RDA for this nutrient through a varied diet. Avoid overcooking and freezing these foods, as these processes can rapidly degrade the Vitamin B6 they contain.

Tuna is a food with a high Vitamin B6 content.
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How do people benefit from healthy Vitamin B6 levels?

It is important to maintain high enough levels of Vitamin B6 in the blood for optimal health. This will also help prevent and even treat certain chronic illnesses. We’ve listed some of the many benefits linked with Vitamin B6 intake for you below:

  • Improvement of inflammation: Certain studies have shown that a reduction in the number of inflammatory molecules in the body is induced by Vitamin B6 supplementation. This could lead to relief of inflammation in illesses like rheumatoid arthritis.
  • Improvement of eye health: Vitamin B6, together with other antioxidant nutrients, is used to prevent and treat age-related macular degeneration (ARMD), a major cause of blindness in the elderly.
  • Improvement in cardiovascular health: A group of individuals took Vitamin B6 supplements for two years. A reduction in cardiovascular risk was observed compared to other people who were given a placebo.
  • Relief from the side effects of oral contraceptives: Many women suffer unpleasant side effects due to contraceptive use, which include nausea, headache, altered appetite and mood swings. Trials have proven that taking Vitamin B6 supplements could fight these discomforts.
  • Relief from the symptoms of premenstrual syndrome: Hormonal imbalances that occurs days – or even weeks – before and during menstruation may lead to undesirable symptoms for some women: headaches, insomnia, sadness and irritability. In certain cases, Vitamin B6 is said to be capable of combating these symptoms.
  • Increased efficacy of anti-anemia treatment: Vitamin B6 is essential for the formation of hemoglobin and red blood cells. Administering it to individuals suffering from iron deficiency has been shown to contribute to raising hemoglobin levels, therefore improving anemia.
  • Relief from depressive symptoms: While there is no proof that Vitamin B6 alone is an effective treatment for depression, studies have shown that maintaining sufficient levels of this nutrient relieves depression symptoms and facilitates their treatment.
  • Relief from nausea in pregnant women: Several studies have demonstrated the effectiveness of Vitamin B6 in treating morning sickness during pregnancy. Moreover, several medicines used to treat this condition contain Vitamin B6.
  • Decrease in cancer incidence: Certain studies have shown that Vitamin B6 presents anti-inflammatory and antioxidant properties that have been linked with a lower incidence of cancer. That being said, note that these studies have yet to be officially confirmed.

Vitamin B6 appears to present properties that are very beneficial for our overall health and well-being. However, many of the uses listed above remain under study and need to be confirmed with a larger population sample. This is why they cannot replace medical evaluation and treatment by a qualified professional.

Active people can supplement with Vitamin B6 before strenuous physical activities.
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What are the different types of Vitamin B6 supplements?

Vitamin B6 is most frequently found in addition to other dietary supplements, in particular multivitamin supplements. That being said, you can also find compound supplements containing only vitamin B6 on the market. These products generally come in the following two forms:

  • Pyridoxine hydrochloride: This form of Vitamin B6 is the best-known and most widely-used in the field of supplementation. It is easy to find and relatively inexpensive.
  • Pyridoxal phosphate (PLP): Also known as Pyridoxal-5-Phosphate (P5P), this is the active form of Vitamin B6. Your liver doesn’t need to metabolize this version of Vitamin B6 in order for it carry out its function, which is why this supplement is more potent than pyridoxine hydrochloride.

Various health authorities have recently banned another natural form of Vitamin B6 called pyridoxamine. Unlike other forms of Vitamin B6, its intake is considered to be dangerous to health. Supplements that are correctly approved by the relevant authorities will never count pyridoxamine as one of their ingredients.

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Did you know that Vitamin B6 in the form of pyridoxine has been used as an antidote for poisoning by fungi or mushrooms?

How should I take my Vitamin B6 supplements?

What dose? Remember that the RDA of Vitmain B6 for healthy adults is very low, at only 1.7 mg/day. In medical practice, doses of up to 20 mg of Vitamin B6 have been used to obtain cognitive and intellectual improvement. One thing is certain: you are strongly advised not to exceed 100 mg of Vitamin B6 per day.

When? This will depend a lot on your lifestyle and personal preferences. You may decide to use this supplement as an energy boost at specific times (before demanding training or during stressful situations). If you wish to take it as a daily supplement, you are encouraged to do so first thing in the morning.

With or without food? You can take Vitamin B6 with or without food. These water-soluble supplements are have a very high bioavailability – the percentage of useful substance that reaches your bloodstream – of around 75%. This means that absorbing them isn’t a problem for the majority of people.

Lentil soup is a great option if you want to consume both Vitamin B6 and protein.
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What are the benefits of supplementing with Vitamin B6?

There is strong scientific evidence proving that Vitamin B6 supplements can be used to treat certain hereditary anemias, to prevent the side effects of certain medications, for seizures in children, and as treatment of neuritis (pain and inflammation of peripheral nerves).

Beyond medical practice, supplementation enthusiasts use these products as “nootropics,” a term that refers to compounds or medicines that enhance cognitive function. Many users of Vitamin B6 have claimed to feel an immediate improvement of their intellectual capacities after intake.

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The word nootropic is a neologism formed from the Greek words nous (mind) and tropos (direction). The term was first coined by Dr. Corneliu Giurgea in 1972.

This nootropic effect is more intensely felt by individuals over the age of forty whose Vitamin B6 production is declining, and who are therefore recommended to use these supplements every day. Younger people will experience a more discreet gain of energy during particularly demanding work or academic situations.

Who can most benefit from Vitamin B6 supplements?

As mentioned above, older individuals who notice a decline in their cognitive function are the people to benefit most often from supplementing with Vitamin B6. The antioxidant function of this compound protects their neurons and sensory cells throughout the body, therefore helping to keep brain aging at bay.

Women of reproductive age – in particular those using oral hormonal contraceptives – can also reap the mood-stabilizing benefits of Vitamin B6. It has been proven that doses of 20-50 mg/day of this supplement could alleviate the symptoms linked to menstruation and contraceptive treatment.

Depression is a complex illness that requires a medical, psychological and social approach. Optimal Vitamin B6 levels can contribute to its treatment.
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Last but not least, fitness fans looking to increase their muscle mass or lose weight will also benefit from adding Vitamin B6 supplements to their diet. This compound is essential for the transport of amino acids needed for muscle synthesis, the transport of fatty acids and glucose metabolism.

Can I take too much Vitamin B6?

Intake of this water-soluble vitamin through food is considered to be completely safe and no Vitamin B6 poisoning via food has ever been reported. However, note that severe toxic effects with potentially irreversible consequences have been linked with the use of high-dose Vitqamin B6 supplements (100-600 mg/day).

Excessive Vitamin B6 supplementation may lead to early sensory side effects that may include tingling or numbness in the hands and feet. In the long run, you may experience nausea, gastro-oesophageal reflux, sensitivity to light, as well as painful and unsightly skin lesions.

Nuts such as pistachios have a high Vitamin B6 content.
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Experts have established intake limits for Vitamin B6 supplements. In the table below, we have listed the maximum recommendations for the different population groups. Note that children under the age of three are not included, as they should not take any type of Vitamin B6 supplement unless recommended by a competent physician.

Population group Tolerable Upper Intake Limit (mg)
Children aged 1 to 3 30
Children aged 4 to 8 40
Children aged 9 to 13 60
Teenagers aged 14 to 18 80
Adults over the age of 18 100

What precautions should I observe when taking Vitamin B6 supplements?

Vitamin B supplements are considered to be completely safe for most people if taken properly and below the 100 mg toxicity limit. In case you experience nausea, diarrhea, vomiting or unpleasant sensory sensations during supplementing, you are strongly encouraged to discontinue use and seek medical help immediately.

National Institutes of HealthU.S. Department of Health & Human Services

“Chronic administration of 1–6 g oral pyridoxine per day for 12–40 months can cause severe and progressive sensory neuropathy characterized by ataxia (loss of control of bodily movements). Symptom severity appears to be dose dependent, and the symptoms usually stop if the patient discontinues the pyridoxine supplements as soon as the neurologic symptoms appear.”

Vitamin B6 consumers should also consider the potential interactions of their supplement with their usual pharmacological treatment. This substance may interact with the following medicines, unpredictably increasing or decreasing their effectiveness, with potential side effects on one’s health:

  • Amiodarone (antiarrhythmic)
  • Phenobarbital (anticonvulsant)
  • Phenytoin (anticonvulsant)
  • Levodopa (Parkinson’s treatment)
  • Oestrogens (contraceptives, replacement therapy)

It is true that Vitamin B6 supplements are frequently used to treat nausea during pregnancy, to prevent and alleviate the symptoms of pre-eclampsia and as a food supplement during breastfeeding. That being said, their use should in no case be done alone and the supplementation needs to be supervised by a clinician.

What is the average price of Vitamin B6 supplements?

Manufacturers tend to sell Vitamin B6 supplements at around 5 to 10 dollars per bottle of 100 tablets/capsules. The most expensive products generally come from nationally or internationally renowned brands, or contain other ingredients – such as zinc, L-carnitine or magnesium – that provide additional properties to the product, naturally increasing its cost.

We strongly encourage you to look out for bulk products and certain offers and promotions that could greatly reduce the end price of the supplement. Considering these products have a very long shelf life, you can make the most of the discounts available and keep the supplements for when you need them.

Shopping Criteria

Choosing the right supplement is essential if you want to make the most of your Vitamin B6 intake. A quality product will contribute to the improvement of your overall physical and mental health. On the other hand, a supplement of poor quality can even put your health at risk. This is why we’ve detailed below some of the key aspects you should evaluate when making your purchase:

  • Vegan or vegetarian nutrition
  • Allergens
  • Combination with other supplements
  • Dosage and safety
  • Dosage form
  • Price/quality ratio

Vegan or vegetarian nutrition

While a varied vegetarian or vegan diet can theoretically provide enough Vitamin B6, the reality is that a large percentage (approximately 28%) of people who follow plant-based diets do not meet their RDA of Vitamin B6. These individuals are therefore encouraged to use Vitamin B6 supplements.

Vegan and vegetarian individuals naturally need to opt for products made from vegetable ingredients only. In that regard, you’ll want to ensure that the raw material and capsule of the supplement are free of animal products. Nowadays, supplements contain a quality seal that guarantees the suitability of this product for vegan consumers.

Allergens

To date, there have been no reports of allergic reactions derived from the consumption of foods rich in Vitamin B6. Paradoxically, Vitamin B6 supplements may trigger allergies, generally in the form of skin inflammation and/or itching. If you experience any of these symptoms, discontinue its use immediately and seek medical attention.

Combination with Other Supplements

As we stated earlier, Vitamin B6 is frequently associated with other supplement products. Considering that this compound is highly versatile, it is often used it to enhance or improve the actions of other nutritional supplements. We’ve listed some of the most common combinations in the table below:

Combination Effect Usefulness
Vitamin B6 + Vitamin B12 Neural protection. Creation of new cells (in particular red blood cells). Food supplement for strict vegans. Treatment of anemia. Energy gain.
Vitamin B6 + Other vitamins of the group B Regulation of cellular metabolism. Neural protection. Strengthening of the immune system. Cellular growth and replication. Regulation of energy production. General improvement of physical health. General improvement of mental health. Protection against infections. Food supplement in restrictive diets.
Vitamin B6 + Melatonin  Regulation of the circadian rhythm. Regulation of energy production. Improvement of the quality of sleep. Reduced fatigue.
Vitamin B6 + Magnesium  Protein synthesis. Synthesis of neurotransmitters. Production of immune system elements. Regulation of energy production. Reduction of fatigue. General improvement of the physical health. General improvement of the mental health. Protection against infections. Formation of new red blood cells. Maintenance of normal glucose metabolism.
Vitamin B6 + Zinc  Synthesis of neurotransmitters. Production of immune system elements. General improvement of the physical health. General improvement of the mental health. Protection against infections.
Vitamin B6 + Vitamin C Antioxidant function. Protein synthesis. Synthesis of neurotransmitters. Anti-inflammatory action. Relief of premenstrual tension. Relief of carpal tunnel symptoms.
Vitamin B6 + L-carnitine  Increased L-carnitine levels. Protein synthesis. Synthesis of neurotransmitters. Regulation of energy production. Activation of the mechanisms to create energy from fatty acids. Maintenance of normal glucose metabolism. Reduction of fatigue. Increased athletic performance.

Dosage and safety

Many manufacturers of supplements sell products with very high Vitamin B6 doses. However, keep in mind that the recommended daily allowance of this nutrient is actually quite low (1.7 mg for most people) and that excessive intake will expose you to unpleasant side effects.

We encourage you to opt for a supplement with a dose ranging between 2 and 50 mg/day, without ever exceeding the upper limit of 100 mg per day. Start supplementing with the lowest effective dose possible, and increase it if and when you experience no side effects or do not get the expected results.

Dosage form

On the U.S. market, you will find Vitamin B6 supplements in liquid, powder and tablet form. The bioavailability of this product is high, which is why the dosage form will not have a marked influence on its effectiveness. In that regard, simply choose the format that best suits your needs and personal preferences.

Value for money

We do not recommend that you pay more for a supplement that offers a very high Vitamin B6 content. The market offers many products with limited quantities at very affordable prices. You’ll gain much more advantage from these lower-dose versions than supplements with excessive doses–which can be dangerous to your health.

Summary

Vitamin B6 is an indispensable nutrient essential to maintaining physical and mental health, as we get older in life. Supplements of this vitamin are incredibly versatile and can be combined with other compounds which can offer various additional benefits.

Remember that the best way to reap the rewards of Vitamin B6 is to moderate your supplement intake. You should absolutely avoid exceeding the recommended doses, as this is likely to  endanger your health. You can simply and effectively supplement with small quantities. Your overall health, and your wallet will appreciate this “less is more” approach.

If you enjoyed this shopping guide on Vitamin B6, feel free to leave us a comment in the section below. You can also share this article on your social media.

(Source of featured image: Sudnitskaya: 81385160/ 123rf.com)

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