Last updated: 16/10/2022

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Welcome to our big D-Mannose test 2023. Here we present all the D-Mannose products that we have tested in detail. We have compiled detailed background information and added a summary of customer reviews on the internet.

We would like to make your purchase decision easier and help you find the best D-Mannose product for you. You will also find answers to frequently asked questions in our guide. If available, we also offer interesting test videos. Furthermore, you will also find some important information on this page that you should definitely pay attention to if you want to buy D-mannose.

The most important facts

  • D-mannose is a simple sugar that is produced by the body itself in small quantities and is available on the market as a food supplement.
  • The substance has the ability to bind bacteria to itself and excrete them through the urine. Therefore, it is mainly used for prophylaxis and supportive treatment of cystitis.
  • Unlike antibiotics, D-mannose has no side effects and is a very tolerable alternative for long-term treatment for many users.

The Best D-Mannose: Our Picks

Guide: Questions you should ask yourself before buying D-Mannose

What exactly is cystitis?

A bladder infection, also known as cystitis in medical terms, is an infection of the urinary bladder or urinary tract. The cause of the infection is usually bacteria of the genus Escherichia coli, but viruses, mycoplasma or chlamydia can also be the trigger.

A urinary tract infection (also known as cystitis) can be very annoying, but above all very painful. Doctors usually prescribe an antibiotic to treat it, which has to be taken for between two days and a week. (Source: / Santos R.)

The typical symptoms take the form of:

  • Pain in the abdomen
  • Blood in the urine
  • frequent urge to urinate
  • Pain and burning when urinating

If a bladder infection is not recognised and treated in time, it can develop into a kidney pelvis infection. The doctor usually takes a urine sample and uses a test stick to determine how bad the infection has progressed.

Urinary tract infections can be very persistent, which is why some patients have them come back again and again, or have them become chronic.

What exactly is D-mannose?

The so-called mannose is a simple sugar that is a natural part of the human body. It is related to the well-known glucose, but is hardly metabolised by the human body. This means that after ingestion, it simply passes through the body and is excreted unchanged. A distinction is made between D-mannose and L-mannose.

D-mannose is the most similar to the substance in the body and is drawn from raw materials such as birch, beech and maize on the dietary supplement market. L-mannose, on the other hand, originates from a chemical process and is only synthetically accessible.

For what purposes is D-mannose used?

The products available on the market are used for the prevention and supportive treatment of cystitis. (1, 2, 3) Unlike antibiotics, the ingredients of D-mannose are already known to the body, which is why there is a very high tolerance rate. (4)

In the field of alternative medicine, people have therefore been trying for some time to find another way of treatment. Doctors and scientists are not yet in complete agreement about the effectiveness of D-mannose, but they cannot deny that there are one or two patients who benefit from taking it. (Source: / Starikov A.)

To treat cystitis, D-mannose uses its unique ability to bind bacteria to itself. After ingestion, it travels through the body, all the way to the urinary tract, where it binds to the harmful bacteria responsible for cystitis. The body then excretes both the D-mannose and the harmful bacteria.

How is D-mannose taken correctly?

D-mannose is regularly offered on the market in the form of a powder. This is dissolved in water in a prescribed dosage of about two grams and drunk. There are two options for treatment:

  • Prophylaxis
  • supportive measure

To prevent cystitis, the D-mannose is taken once a day, over a period of about 30 days. For supportive treatment, on the other hand, the recommended dosage is as follows:

  • 1.-3. day = 3x daily
  • 4.-5. day = 2x daily

In supportive treatment, it is not only important to take in enough fluids to promote the healing process. It is also important to take a larger amount of D-mannose during this time, as indicated on the recommended dosage. To ensure success afterwards, it is also planned to continue the treatment for another 30 days. During this time, it is sufficient to take it once a day.

Are there certain risk groups for cystitis?

In principle, cystitis can affect anyone, regardless of whether they are male or female and regardless of what age group they are in. However, there are certain groups for whom taking D-mannose is particularly beneficial because they are more prone to developing cystitis. These include:

  • Women with chronic cystitis
  • Pregnant women
  • Children
  • Women going through menopause
  • People taking certain medicines

It has already been scientifically proven that women are generally more prone to developing a urinary tract infection. Due to the position of their genitals, they are more susceptible to bacteria entering the urinary tract and causing cystitis.

Pregnancy, for example, makes women particularly susceptible to urinary tract infections. The situation is similar with the menopause, during which the hormonal balance undergoes extreme changes. Persistent bladder infections or those that recur again and again are often the affliction of aging women.

The risk of bladder infections can be very high, especially in pregnant women. Therefore, pregnant women should pay close attention and take preventive measures. ( Source: )

Especially with children, parents are always worried if they have to take an antibiotic. D-mannose, on the other hand, has a sweet taste and offers a good alternative if taking antibiotics is not desired.

Decision: What types of D-mannose are there and which is the right one for you?

Basically, you can distinguish between four different types of D-mannose:

  • Powder
  • Capsules
  • Tablets
  • Granules

What is D-mannose powder and what are the advantages and disadvantages of D-mannose powder?

This is the most common form of administration. It is simply dissolved in water and taken. A big advantage is that people with intolerances to gluten or the like do not have to worry that any additives may have been used in the processing.

Most products are also suitable for vegetarians and vegans. Individual dosage rounds off this form of administration.

  • Uncomplicated to take
  • Sweetish taste
  • Easily available
  • Offered by different manufacturers
  • Through the liquid, the substance quickly reaches its destination
  • Can be perfectly dosed
  • Cannot be taken everywhere due to the need for water

What are D-mannose capsules and what are the advantages and disadvantages of D-mannose capsules?

In principle, the D-mannose powder is contained in a capsule. A big advantage of this variant is that it is simply taken with a little water. It dissolves in the stomach and the D-mannose is transported further.

However, this also means that the effect is somewhat delayed. In addition, unlike the powder, they are not particularly easy to dose if a different amount needs to be taken.

  • Easy to take, with only a little water
  • Also uncomplicated in everyday working life
  • Cannot be dosed individually if necessary
  • Time-delayed effectiveness because the capsule has to dissolve first
  • Only available on the market from a few manufacturers

What are D-mannose tablets and what are the advantages and disadvantages of D-mannose tablets?

D-mannose tablets are basically compressed pellets that are compactly packaged in a blister in a certain dosage amount. One advantage over capsules is that they can be divided, depending on the manufacturer, and are therefore easier to dose.

However, they do not come close to the powder in this respect. Furthermore, the tablets are also more suitable for everyday use, as they only need to be taken with a little liquid.

  • Easy to take with a little water
  • therefore very suitable for everyday use
  • can be divided and thus dosed, depending on the manufacturer
  • Effect is delayed, as they first have to dissolve
  • Only offered sporadically on the market

What is D-mannose granulate and what are the advantages and disadvantages of D-mannose granulate?

In principle, the granulate works in the same way as the powder, but is somewhat coarser-grained and is dissolved in water. The dosage is similar, so that you can perfectly adjust the products to your own needs.

In everyday life, however, the granules also prove to be a small problem, as water is always required for ingestion. Nevertheless, it can hold a candle to the powder in every respect.

  • Offered in this form by several manufacturers
  • Sweetish taste
  • Free dosage possible
  • Quickly absorbed and passed on by the body
  • Uncomplicated intake possible
  • Not applicable everywhere due to the need for water

Buying criteria: You can use these factors to compare and evaluate D-mannose

In the following, we would like to show you which factors you can use to compare and evaluate D-mannose. This will make it easier for you to decide whether a certain D-mannose product is suitable for you or not. In summary, these are:

  • Application
  • Dosage
  • Raw material
  • Shelf life


This criterion is really only about which method of intake you prefer. Do you prefer to take tablets or juice? Here is a small overview that you can use as a guide:

Dosage form ideal for
Powder/granules easier to take, larger packages available, offered by numerous manufacturers, better dosage possible, ideal alternative for children, sweetish taste, for swallowing difficulties
Tablets can be divided and dosed in a limited way if necessary, easy to take without much liquid, therefore suitable for everyday use
Capsules uncomplicated to take, suitable for everyday use

If you want to treat your child, for example, a powder might be more advisable, as it can be dissolved in water and then easily drunk. Because of the sweet taste, the little ones prefer this intake variant rather than tablets. The same applies to granules.

However, if you are on the road every day and do not necessarily have the possibility to mix the drink, capsules and tablets are an alternative. These should also be taken with liquid, but you do not have to mix them separately.

With these forms of administration, you should also bear in mind that they are not available from every manufacturer and you will have to go by what the pharmacy has to offer.


Both powders and granules in sachets are usually in fixed doses. The same applies to tablets and capsules. The advantage of tablets is that they are usually divisible, so that the dosage can be at least halved if necessary.

With powders, separate weighing is required, but in principle they can also be freely dosed. However, some patients require a higher dose, which is agreed with their doctor. Free dosing is therefore indispensable in this case.

Raw material

D-mannose is drawn from various sources. The following raw materials are the most commonly used:

  • Birch
  • Beech
  • Maize

Particularly with maize, there is often a risk that it is genetically manipulated. Therefore, when choosing the right preparation, it is important to pay attention to the quality of the raw materials used.

Although there are manufacturers who clearly declare on their products that no genetically manipulated maize has been used, one cannot be 100 per cent sure.

Alternatives such as D-mannose from beech or birch are also available on the market, but they are not as numerous as the maize variant. Therefore, when choosing the right product, it is important to seek detailed information in advance.

Furthermore, it can also play a role that – for whatever reason – neither tablets nor capsules can be taken. For example, if there is difficulty swallowing. In such cases, granules and powders are the obvious choice because they are easy for the user to take. (Source: / kanys)

Shelf life

Generally, products on the market are dated to last for a longer treatment cycle. However, this factor becomes important with products that are packaged as powder in a bag, for example. Usually, granules and powders are individually packaged in portions and sealed accordingly.

The best-before date is printed on the reverse side of the packaging, usually on the bottom flap. In the case of free-dose packaged remedies, it is important to ensure that the contents are consumed promptly after opening. As a rule, this use-by date is between six and twelve months.

The exact indication and observance is mainly important if the contents are taken over a certain period of time and then a longer break is taken in order to continue the treatment later. The date should therefore be set in such a way that taking it is still justifiable and corresponds to the use-by or best-before date.

Facts worth knowing about D-mannose

Can D-mannose cause any side effects?

D-mannose is usually considered a very well-tolerated product, as it is produced by the body itself in small quantities. However, the question of whether side effects may occur can be answered as follows: “It’s the quantity that counts! Excessive amounts are particularly addressed here, which can definitely lead to side effects.

These usually take the form of gastrointestinal complaints, diarrhoea and nausea. It is therefore advisable to always follow the manufacturer’s dosage recommendation and not to take more than is indicated. Moreover, this will not lead to a better effect.

Can I take D-mannose on suspicion?

Since the simple sugar is produced by the body itself in small quantities, the additional intake of D-mannose is not such an intervention for it as, for example, an antibiotic. Nevertheless, taking it on suspicion is not necessarily recommended.

An inflammation of the bladder should always be examined by an appropriate doctor. Regarding treatment, the severity of the disease always plays a role and in some cases recovery is no longer possible without a special medication.

However, D-mannose can be a suitable additional treatment in such situations. However, the use of D-mannose should always be discussed with the doctor beforehand.

Is there scientific evidence for the effectiveness of D-mannose?

There are still relatively few scientific studies on the topic of D-mannose that are really meaningful. Often the comparisons within the study are blurred, or there are other problems. However, the Ärzte-Zeitung reported on a controlled study in which D-mannose was compared with the antibiotic nitrofurantoin.

This was mainly to prove that D-mannose is just as suitable for prophylaxis as the corresponding antibiotic. Within the framework of this study, the test persons had already been treated with an antibiotic (ciprofloxacin) over a period of seven days.

Afterwards, they were divided into three groups, one of which received D-mannose as prophylaxis, the second was treated with nitrofurantoin and the third group received no further treatment. After a period of six months, it was found that only 15 percent of the women in the D-mannose group had developed the pathogens again.

The percentage of those who had not received any treatment was as high as 61 per cent, and 21 per cent of the women on nitrofurantoin had pathogens. Overall, the group that had received D-mannose as prophylaxis had performed best.

Image source: / kaboompics

References (4)

1. Bojana Kranjčec, Dino Papeš, Silvio Altarac. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World Journal of Urology. 2014; volume 32, pages79–84.

2. D Porru, A Parmigiani, C Tinelli et al. Oral D-mannose in recurrent urinary tract infections in women: a pilot study. Journal of Clinical Urology. January 10 2014.

3. Hung CS, Bouckaert J, Hung D, Pinkner J et al. Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. Mol Microbiol. 2002 May;44(4):903-15.

4. Davis JA, Freeze HH. Studies of mannose metabolism and effects of long-term mannose ingestion in the mouse. Biochim Biophys Acta. 2001 Oct 3;1528(2-3):116-26.

Wissenschaftliche Studie
Bojana Kranjčec, Dino Papeš, Silvio Altarac. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World Journal of Urology. 2014; volume 32, pages79–84.
Go to source
Wissenschaftliche Studie
D Porru, A Parmigiani, C Tinelli et al. Oral D-mannose in recurrent urinary tract infections in women: a pilot study. Journal of Clinical Urology. January 10 2014.
Go to source
Wissenschaftliche Studie
Hung CS, Bouckaert J, Hung D, Pinkner J et al. Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. Mol Microbiol. 2002 May;44(4):903-15.
Go to source
Wissenschaftliche Studie
Davis JA, Freeze HH. Studies of mannose metabolism and effects of long-term mannose ingestion in the mouse. Biochim Biophys Acta. 2001 Oct 3;1528(2-3):116-26.
Go to source